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伊那分室の機器を利用した業績
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2023年度
Watanabe, S., Haruyama, R., Umezawa, K., Tomioka, I., Nakamura, S., Katayama, S., & Mitani, T. (2023). Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes. The Journal of Nutritional Biochemistry, 109433.
https://doi.org/10.1016/j.jnutbio.2023.109433
Yamanaka, K., Inoue, Y., Imanishi, M., & Ohkanda, J. (2023). Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors. Bioorganic & Medicinal Chemistry Letters, 129588.
https://doi.org/10.1016/j.bmcl.2023.129588
Kawamura, A., Mizuno, A., Kurakake, M., Yamada, A., & Makabe, H. (2024). Inaoside A: New antioxidant phenolic compound from the edible mushroom Laetiporus cremeiporus. Heliyon, 10(3).
https://doi.org/10.1016/j.heliyon.2024.e24651
Kameyama, Y., & Makabe, H. (2023). Application of Pd-catalyzed carbonylation followed by spontaneous oxa-Michael addition/diastereoselective reduction of ynone: Synthesis of (+)-goniofufurone. Tetrahedron Letters, 132, 154827.
https://doi.org/10.1016/j.tetlet.2023.154827
Sawa, T., Endo, K., Nakashima, A., Tanaka, Y., Makabe, H., & Tanaka, S. (2023). Procyanidin B2 3, 3′′-di-O-gallate ameliorates imiquimod-induced skin inflammation by suppressing TLR7 signaling through the inhibition of endosomal acidification in dendritic cells. International Immunopharmacology, 121, 110444.
https://doi.org/10.1016/j.intimp.2023.110444
Tanaka, Y., Inaba, C., Sawa, T., Endo, K., Saiki, T., Haga, H., & Tanaka, S. (2023). Brassica rapa L. prevents Western diet-induced obesity in C57BL/6 mice through its binding capacity of cholesterol and fat. Bioscience, Biotechnology, and Biochemistry, 87(10), 1205-1211.
https://doi.org/10.1093/bbb/zbad086
Endo, K., Sawa, T., Tanaka, Y., Saiki, T., Haga, H., Rizeq, L., ... & Tanaka, S. (2023). Oral administration of procyanidin B2 3, 3"-di-O-gallate ameliorates experimental autoimmune encephalomyelitis through immunosuppressive effects on CD4+ T cells by regulating glycolysis. European Journal of Pharmacology, 954, 175879.
https://doi.org/10.1016/j.ejphar.2023.175879
Matsui, R., Endo, K., Saiki, T., Haga, H., Shen, W., Wang, X., ... & Tanaka, S. (2024). Characterization and anti-tumor activities of polysaccharide isolated from Brassica rapa L. via activation of macrophages through TLR2-and TLR4-Dependent pathways. Archives of Biochemistry and Biophysics, 752, 109879.
https://doi.org/10.1016/j.abb.2023.109879
Tanaka, K., Hatano, Y., & Ohkanda, J. (2023). Isoform‐Selective Fluorescent Labeling of 14‐3‐3σ by Acrylamide‐Containing Fusicoccins. Chemistry–A European Journal, 29(41), e202301059.
https://doi.org/10.1002/chem.202301059
2022年度
Kimura, N., Saito, K., Niwa, T., Yamakawa, M., Igaue, S., Ohkanda, J., Hosoya T, Kii, I. (2022). Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY. Protein Expression and Purification, 195, 106089.
https://doi.org/10.1016/j.pep.2022.106089
Tanaka, Y., Kobayashi, S. H., Hattori, Y., Kawamura, A., Makabe, H. (2022). Concise Synthesis of Procyanidin B2 3, 3′′-Digallate Using Yb (OTf) 3-Mediated Self-Condensation. Synlett. 33(11): 1071-1074
https://doi.org/10.1055/s-0041-1737457
Ogino, N., Masuda, R., Punzalan, L. L., Yamashita, E., Igaue, S., Inoue, Y., & Ohkanda, J. (2022). Structure-Activity-Relationship Study of Semi-synthetically Modified Fusicoccins on their Stabilization Effect for 14-3-3-phospholigand Interactions. Bioorganic & Medicinal Chemistry, 117020.
https://doi.org/10.1016/j.bmc.2022.117020
Asami, T., Endo, K., Matsui, R., Sawa, T., Tanaka, Y., Saiki, T., ... & Tanaka, S. (2022). Long-term caloric restriction ameliorates T cell immunosenescence in mice. Mechanisms of Ageing and Development, 206, 111710.
https://doi.org/10.1016/j.mad.2022.111710
Irieda, H. (2022). Emerging Roles of Motile Epidermal Chloroplasts in Plant Immunity. International Journal of Molecular Sciences, 23(7), 4043.
https://doi.org/10.3390/ijms23074043
Endo, K., Sawa, T., Kitamura, H., Umezawa, K., Makabe, H., & Tanaka, S. (2023). Procyanidin B2 3, 3 ″-di-O-gallate suppresses IFN-γ production in murine CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT2. International Immunopharmacology, 115, 109617.
https://doi.org/10.1016/j.intimp.2022.109617
Tanaka, S. (2023). Modulation of immune function and changes in intestinal flora by Brassica rapa L.(Nozawana). Bioscience, Biotechnology, and Biochemistry,87(5), 465-472.
Miyazaki, Y., Kikuchi M., Umezawa, K., Descamps, A., Nakamura, D., Furuie, G., Sumida, T., Saito, K., Kimura, N., Niwa, T., Sumida, Y., Umehara, T., Hosoya, T., & Kii, I. (2021) Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A, European Journal of Medicinal Chemistry, Volume 227, 113948.
https://doi.org/10.1016/j.ejmech.2021.113948
Ikeda, T., Watanabe, S., & Mitani, T. (2021). Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria. Bioscience, Biotechnology, and Biochemistry, zbab203. https://doi.org/10.1093/bbb/zbab203
Mitani, T., Tanaka, E., Nakashima, M., Yonemoto, E., Fujii, H., & Ashida, H. (2021). Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner. The Journal of Nutritional Biochemistry, 108898.
https://doi.org/10.1016/j.jnutbio.2021.108898
Irieda, H., & Takano, Y. (2021). Epidermal chloroplasts are defense-related motile organelles equipped with plant immune components. Nature communications, 12：2736. https://doi.org/10.1038/s41467-021-22977-5
Sugimoto, M., Nosho, S., Hikosaka, G., Hattori, Y., Umezawa, K., Kawamura, A., & Makabe, H. (2021). Synthesis of (+)-Muconin via Diastereoselective Oxypalladation. The Journal of organic chemistry, 86(6), 4859-4866. https://doi.org/10.1021/acs.joc.0c02831
Suzuki, K., Hattori, Y., Kawamura, A., & Makabe, H. (2021). Synthesis of (+)-solenopsin via Pd-catalyzed N-alkylation and cyclization. Bioscience, Biotechnology, and Biochemistry, 85(2), 223-227. https://doi.org/10.1093/bbb/zbaa014
Nagaoka, Y., Parvatkar, P., Hirai, G., & Ohkanda, J. (2021). Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B. Bioorganic & Medicinal Chemistry Letters, 48, 128265. https://doi.org/10.1016/j.bmcl.2021.128265
Kawahara, T., Ito, A., Kiso, A., Kawamoto, F. (2021). Inhibitory effect of strawberry geranium (Saxifraga stolonifera) on Toll-like receptor 2-mediated inflammatory response in human skin keratinocytes. Journal of Ethnopharmacology 275 (2021) 114039.
https://doi.org/10.1016/j.jep.2021.114039
Takahashi, F., Endo, K., Matsui, R., Yamamoto, K., Tanaka, S. (2021). Brassica rapa L. activates macrophages via Toll-like receptors. Bioscience, Biotechnology, and Biochemistry, 85(3), 656-665.
https://doi.org/10.1093/bbb/zbaa075
Ngyuen, C. T., Ezawa, T., Saito, K. (2022) Polyphosphate polymerizing and depolymerizing activity of VTC4 protein in an arbuscular mycorrhizal fungus. Soil Science and Plant Nutrition. 68(2), 256-267. https://doi.org/10.1080/00380768.2022.2029220
Ngyuen, C. T., Saito, K. (2021) Role of cell wall polyphosphates in phosphorus transfer at the arbuscular interface in mycorrhizas. Frontiers in Plant Science. 12, 725939. https://doi.org/10.3389/fpls.2021.725939
Sugiura, Y., Akiyama, R., Tanaka, S., Yano, K., Kameoka, H., Marui, S., Saito, M., Kawaguchi, M., Akiyama, K., Saito, K. (2020) Myristate can be used as a carbon and energy source for the asymbiotic growth of arbuscular mycorrhizal fungi. Proceedings of the National Academy of Sciences of the United States of America. 117(41), 25779-25788. https://doi.org/10.1073/pnas.2006948117
Kameoka, H., Tsutsui, I., Saito, K., Kikuchi, Y., Handa, Y., Ezawa, T., Hayashi, H., Kawaguchi, M., Akiyama, K. (2019) Stimulation of asymbiotic sporulation in arbuscular mycorrhizal fungi by fatty acids. Nature Microbiology. 4(10), 1654-1660. https://doi.org/10.1038/s41564-019-0485-7
Okajima, T., Shigemori, S., Namai, F., Ogita, T., Sato, T. & Shimosato, T. (2021) Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice. Frontiers in Immunology, 12:738041, https://doi.org/10.3389/fimmu.2021.738041
Tanaka S, Yamamoto K, Hamajima C, Takahashi F, Endo K, Uyeno Y. Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure. Nutrients. 13(6):1847. 2021. https://doi.org/10.3390/nu13061847
2021年度
2020年度
Tsukagoshi, M., Sirisopapong, M., Namai, F., Ishida, M., Okrathok, S., Shigemori, S., Ogita, T., Sato, T., Khempaka, S., & Shimosato, T. (2020). Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS-stimulated mouse macrophages. Animal Science Journal, 91(1), 1–7. https://doi.org/10.1111/asj.13436
Shigemori, S., Namai, F., Ogita, T., Sato, T., & Shimosato, T. (2020). Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate-induced acute colitis in mice. Animal Science Journal, 91(1), 6–11. https://doi.org/10.1111/asj.13468
Namai, F., Shigemori, S., Ogita, T., Sato, T., & Shimosato, T. (2020). Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable. Molecular Biology Reports, 47(9), 7039–7047. https://doi.org/10.1007/s11033-020-05765-0
Namai, F., Murakami, A., Ueda, A., Tsukagoshi, M., Shigemori, S., Ogita, T., Sato, T., & Shimosato, T. (2020). Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable. Molecular Biotechnology, 62(11–12), 572–579. https://doi.org/10.1007/s12033-020-00274-8
Namai, F., Shigemori, S., Ogita, T., Sato, T., & Shimosato, T. (2020). Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice. Experimental and Molecular Medicine, 52(9), 1627–1636. https://doi.org/10.1038/s12276-020-00507-5
Mikami, A., Ogita, T., Namai, F., Shigemori, S., Sato, T., & Shimosato, T. (2020). Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue. Molecular Biology Reports, 47(9), 6717–6725. https://doi.org/10.1007/s11033-020-05727-6
Minori Ishida, Fu Namai, Suguru Shigemori, Shoko Kajikawa, Masami Tsukagoshi, Takashi Sato, Tasuku Ogita, Takeshi Shimosatoa (2020). Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin. Applied and Environmental Microbiology 86(20), 1–10. https://doi.org/10.1128/AEM.01448-20.
Tsubamoto, M., Le, T. K., Li, M., Watanabe, T., Matsumi, C., Parvatkar, P., ... & Ohkanda, J. (2019). A Guanidyl‐Based Bivalent Peptidomimetic Inhibits K‐Ras Prenylation and Association with c‐Raf. Chemistry–A European Journal, 25(59), 13531-13536.
Masuda, R., Kawasaki, Y., Igawa, K., Manabe, Y., Fujii, H., Kato, N., ... & Ohkanda, J. (2020). Copper‐Free Huisgen Cycloaddition for the 14‐3‐3‐Templated Synthesis of Fusicoccin‐Peptide Conjugates. Chemistry–An Asian Journal, 15(6), 742-747.
Mitani, T., Watanabe, S., Wada, K., Fujii, H., Nakamura, S., & Katayama, S. (2020). Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes. Biochemical and Biophysical Research Communications, 522(3), 770-775.
Miyazawa, Y., Sugimoto, M., Tanaka-Oda, A., & Makabe, H. (2019). Synthesis of (+)-goniopypyrone and (+)-goniotriol using Pd-catalyzed carbonylation. Tetrahedron Letters, 60(36), 151039.
Ogita, T., Yamamoto, Y., Mikami, A., Shigemori, S., Sato, T., & Shimosato, T. (2020). Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice. Frontiers in Immunology, 11, 379.
2019年度
2018年度
Junko Ohkanda, Atsushi Kusumoto, Louvy Punzalan, Ryoma Masuda, Chenyu Wang, Prakash Parvatkar, Dai Akase, Misako Aida, Motonari Uesugi, Yusuke Higuchi and Nobuo Kato: Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity. ChemPubSocEurope 24: 16066-16071, 2018.