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伊那分室では、農学部の大型分析装置を一元的に管理・運用し最先端の教育・研究活動を支援しています

伊那分室の機器を利用した業績

​センターの装置を利用して得られた結果を掲載した論文は、謝辞にその旨を記載しPDFをメールでお送りください。

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2023年度

2023年度

Watanabe, S., Haruyama, R., Umezawa, K., Tomioka, I., Nakamura, S., Katayama, S., & Mitani, T. (2023). Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes. The Journal of Nutritional Biochemistry, 109433.
https://doi.org/10.1016/j.jnutbio.2023.109433

Yamanaka, K., Inoue, Y., Imanishi, M., & Ohkanda, J. (2023). Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors. Bioorganic & Medicinal Chemistry Letters, 129588.

https://doi.org/10.1016/j.bmcl.2023.129588

Kawamura, A., Mizuno, A., Kurakake, M., Yamada, A., & Makabe, H. (2024). Inaoside A: New antioxidant phenolic compound from the edible mushroom Laetiporus cremeiporus. Heliyon, 10(3).

https://doi.org/10.1016/j.heliyon.2024.e24651

Kameyama, Y., & Makabe, H. (2023). Application of Pd-catalyzed carbonylation followed by spontaneous oxa-Michael addition/diastereoselective reduction of ynone: Synthesis of (+)-goniofufurone. Tetrahedron Letters, 132, 154827.
https://doi.org/10.1016/j.tetlet.2023.154827

 

Sawa, T., Endo, K., Nakashima, A., Tanaka, Y., Makabe, H., & Tanaka, S. (2023). Procyanidin B2 3, 3′′-di-O-gallate ameliorates imiquimod-induced skin inflammation by suppressing TLR7 signaling through the inhibition of endosomal acidification in dendritic cells. International Immunopharmacology, 121, 110444.

https://doi.org/10.1016/j.intimp.2023.110444


Tanaka, Y., Inaba, C., Sawa, T., Endo, K., Saiki, T., Haga, H., & Tanaka, S. (2023). Brassica rapa L. prevents Western diet-induced obesity in C57BL/6 mice through its binding capacity of cholesterol and fat. Bioscience, Biotechnology, and Biochemistry, 87(10), 1205-1211.

https://doi.org/10.1093/bbb/zbad086


Endo, K., Sawa, T., Tanaka, Y., Saiki, T., Haga, H., Rizeq, L., ... & Tanaka, S. (2023). Oral administration of procyanidin B2 3, 3"-di-O-gallate ameliorates experimental autoimmune encephalomyelitis through immunosuppressive effects on CD4+ T cells by regulating glycolysis. European Journal of Pharmacology, 954, 175879.

https://doi.org/10.1016/j.ejphar.2023.175879

Matsui, R., Endo, K., Saiki, T., Haga, H., Shen, W., Wang, X., ... & Tanaka, S. (2024). Characterization and anti-tumor activities of polysaccharide isolated from Brassica rapa L. via activation of macrophages through TLR2-and TLR4-Dependent pathways. Archives of Biochemistry and Biophysics, 752, 109879.

https://doi.org/10.1016/j.abb.2023.109879


Tanaka, K., Hatano, Y., & Ohkanda, J. (2023). Isoform‐Selective Fluorescent Labeling of 14‐3‐3σ by Acrylamide‐Containing Fusicoccins. Chemistry–A European Journal, 29(41), e202301059.

https://doi.org/10.1002/chem.202301059

2022年度

Kimura, N., Saito, K., Niwa, T., Yamakawa, M., Igaue, S., Ohkanda, J., Hosoya T, Kii, I. (2022). Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY. Protein Expression and Purification, 195, 106089.

https://doi.org/10.1016/j.pep.2022.106089

Tanaka, Y., Kobayashi, S. H., Hattori, Y., Kawamura, A., Makabe, H. (2022). Concise Synthesis of Procyanidin B2 3, 3′′-Digallate Using Yb (OTf) 3-Mediated Self-Condensation. Synlett. 33(11): 1071-1074

https://doi.org/10.1055/s-0041-1737457

Ogino, N., Masuda, R., Punzalan, L. L., Yamashita, E., Igaue, S., Inoue, Y., & Ohkanda, J. (2022). Structure-Activity-Relationship Study of Semi-synthetically Modified Fusicoccins on their Stabilization Effect for 14-3-3-phospholigand Interactions. Bioorganic & Medicinal Chemistry, 117020.

https://doi.org/10.1016/j.bmc.2022.117020

 

Asami, T., Endo, K., Matsui, R., Sawa, T., Tanaka, Y., Saiki, T., ... & Tanaka, S. (2022). Long-term caloric restriction ameliorates T cell immunosenescence in mice. Mechanisms of Ageing and Development, 206, 111710.
https://doi.org/10.1016/j.mad.2022.111710

 

Irieda, H. (2022). Emerging Roles of Motile Epidermal Chloroplasts in Plant Immunity. International Journal of Molecular Sciences, 23(7), 4043.
https://doi.org/10.3390/ijms23074043

 

Endo, K., Sawa, T., Kitamura, H., Umezawa, K., Makabe, H., & Tanaka, S. (2023). Procyanidin B2 3, 3 ″-di-O-gallate suppresses IFN-γ production in murine CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT2. International Immunopharmacology, 115, 109617.
https://doi.org/10.1016/j.intimp.2022.109617

 

Tanaka, S. (2023). Modulation of immune function and changes in intestinal flora by Brassica rapa L.(Nozawana). Bioscience, Biotechnology, and Biochemistry,87(5), 465-472.

https://doi.org/10.1093/bbb/zbad018
 

Miyazaki, Y., Kikuchi M., Umezawa, K., Descamps, A., Nakamura, D., Furuie, G.,  Sumida, T., Saito, K., Kimura, N., Niwa, T., Sumida, Y., Umehara, T., Hosoya, T., & Kii, I. (2021) Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A, European Journal of Medicinal Chemistry, Volume 227, 113948.

https://doi.org/10.1016/j.ejmech.2021.113948

 

Ikeda, T., Watanabe, S., & Mitani, T. (2021). Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria. Bioscience, Biotechnology, and Biochemistry, zbab203.  https://doi.org/10.1093/bbb/zbab203

Mitani, T., Tanaka, E., Nakashima, M., Yonemoto, E., Fujii, H., & Ashida, H. (2021). Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner. The Journal of Nutritional Biochemistry, 108898.

https://doi.org/10.1016/j.jnutbio.2021.108898

Irieda, H., & Takano, Y. (2021). Epidermal chloroplasts are defense-related motile organelles equipped with plant immune components. Nature communications, 12:2736. https://doi.org/10.1038/s41467-021-22977-5

Sugimoto, M., Nosho, S., Hikosaka, G., Hattori, Y., Umezawa, K., Kawamura, A., & Makabe, H. (2021). Synthesis of (+)-Muconin via Diastereoselective Oxypalladation. The Journal of organic chemistry, 86(6), 4859-4866.  https://doi.org/10.1021/acs.joc.0c02831

Suzuki, K., Hattori, Y., Kawamura, A., & Makabe, H. (2021). Synthesis of (+)-solenopsin via Pd-catalyzed N-alkylation and cyclization. Bioscience, Biotechnology, and Biochemistry, 85(2), 223-227.  https://doi.org/10.1093/bbb/zbaa014

Nagaoka, Y., Parvatkar, P., Hirai, G., & Ohkanda, J. (2021). Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B. Bioorganic & Medicinal Chemistry Letters, 48, 128265. https://doi.org/10.1016/j.bmcl.2021.128265

Kawahara, T., Ito, A., Kiso, A., Kawamoto, F. (2021). Inhibitory effect of strawberry geranium (Saxifraga stolonifera) on Toll-like receptor 2-mediated inflammatory response in human skin keratinocytes. Journal of Ethnopharmacology 275 (2021) 114039.

https://doi.org/10.1016/j.jep.2021.114039

Takahashi, F., Endo, K., Matsui, R., Yamamoto, K., Tanaka, S. (2021). Brassica rapa L. activates macrophages via Toll-like receptors. Bioscience, Biotechnology, and Biochemistry, 85(3), 656-665.

https://doi.org/10.1093/bbb/zbaa075

Ngyuen, C. T., Ezawa, T., Saito, K. (2022) Polyphosphate polymerizing and depolymerizing activity of VTC4 protein in an arbuscular mycorrhizal fungus. Soil Science and Plant Nutrition. 68(2), 256-267. https://doi.org/10.1080/00380768.2022.2029220

 

Ngyuen, C. T., Saito, K. (2021) Role of cell wall polyphosphates in phosphorus transfer at the arbuscular interface in mycorrhizas. Frontiers in Plant Science. 12, 725939. https://doi.org/10.3389/fpls.2021.725939

 

Sugiura, Y., Akiyama, R., Tanaka, S., Yano, K., Kameoka, H., Marui, S., Saito, M., Kawaguchi, M., Akiyama, K., Saito, K. (2020) Myristate can be used as a carbon and energy source for the asymbiotic growth of arbuscular mycorrhizal fungi. Proceedings of the National Academy of Sciences of the United States of America. 117(41), 25779-25788. https://doi.org/10.1073/pnas.2006948117

 

Kameoka, H., Tsutsui, I., Saito, K., Kikuchi, Y., Handa, Y., Ezawa, T., Hayashi, H., Kawaguchi, M., Akiyama, K. (2019) Stimulation of asymbiotic sporulation in arbuscular mycorrhizal fungi by fatty acids. Nature Microbiology. 4(10), 1654-1660. https://doi.org/10.1038/s41564-019-0485-7

Okajima, T., Shigemori, S., Namai, F., Ogita, T., Sato, T. & Shimosato, T. (2021) Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice. Frontiers in Immunology, 12:738041, https://doi.org/10.3389/fimmu.2021.738041

Tanaka S, Yamamoto K, Hamajima C, Takahashi F, Endo K, Uyeno Y. Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure. Nutrients. 13(6):1847. 2021. https://doi.org/10.3390/nu13061847

2021年度

2021年度
2022年度

2020年度

Tsukagoshi, M., Sirisopapong, M., Namai, F., Ishida, M., Okrathok, S., Shigemori, S., Ogita, T., Sato, T., Khempaka, S., & Shimosato, T. (2020). Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS-stimulated mouse macrophages. Animal Science Journal, 91(1), 1–7. https://doi.org/10.1111/asj.13436


Shigemori, S., Namai, F., Ogita, T., Sato, T., & Shimosato, T. (2020). Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate-induced acute colitis in mice. Animal Science Journal, 91(1), 6–11. https://doi.org/10.1111/asj.13468


Namai, F., Shigemori, S., Ogita, T., Sato, T., & Shimosato, T. (2020). Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable. Molecular Biology Reports, 47(9), 7039–7047. https://doi.org/10.1007/s11033-020-05765-0


Namai, F., Murakami, A., Ueda, A., Tsukagoshi, M., Shigemori, S., Ogita, T., Sato, T., & Shimosato, T. (2020). Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable. Molecular Biotechnology, 62(11–12), 572–579. https://doi.org/10.1007/s12033-020-00274-8


Namai, F., Shigemori, S., Ogita, T., Sato, T., & Shimosato, T. (2020). Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice. Experimental and Molecular Medicine, 52(9), 1627–1636. https://doi.org/10.1038/s12276-020-00507-5


Mikami, A., Ogita, T., Namai, F., Shigemori, S., Sato, T., & Shimosato, T. (2020). Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue. Molecular Biology Reports, 47(9), 6717–6725. https://doi.org/10.1007/s11033-020-05727-6


Minori Ishida, Fu Namai, Suguru Shigemori, Shoko Kajikawa, Masami Tsukagoshi, Takashi Sato, Tasuku Ogita, Takeshi Shimosatoa (2020). Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin. Applied and Environmental Microbiology 86(20), 1–10. https://doi.org/10.1128/AEM.01448-20.

2020年度
2019年度

Tsubamoto, M., Le, T. K., Li, M., Watanabe, T., Matsumi, C., Parvatkar, P., ... & Ohkanda, J. (2019). A Guanidyl‐Based Bivalent Peptidomimetic Inhibits K‐Ras Prenylation and Association with c‐Raf. Chemistry–A European Journal, 25(59), 13531-13536.

Masuda, R., Kawasaki, Y., Igawa, K., Manabe, Y., Fujii, H., Kato, N., ... & Ohkanda, J. (2020). Copper‐Free Huisgen Cycloaddition for the 14‐3‐3‐Templated Synthesis of Fusicoccin‐Peptide Conjugates. Chemistry–An Asian Journal, 15(6), 742-747.

Mitani, T., Watanabe, S., Wada, K., Fujii, H., Nakamura, S., & Katayama, S. (2020). Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes. Biochemical and Biophysical Research Communications, 522(3), 770-775.

Miyazawa, Y., Sugimoto, M., Tanaka-Oda, A., & Makabe, H. (2019). Synthesis of (+)-goniopypyrone and (+)-goniotriol using Pd-catalyzed carbonylation. Tetrahedron Letters, 60(36), 151039.

Ogita, T., Yamamoto, Y., Mikami, A., Shigemori, S., Sato, T., & Shimosato, T. (2020). Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice. Frontiers in Immunology, 11, 379.
 

2019年度

2018年度

Junko Ohkanda, Atsushi Kusumoto, Louvy Punzalan, Ryoma Masuda, Chenyu Wang, Prakash Parvatkar, Dai Akase, Misako Aida, Motonari Uesugi, Yusuke Higuchi and Nobuo Kato: Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity. ChemPubSocEurope 24: 16066-16071, 2018.

2018年度
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